In recent decades, prostate cancer has emerged as one of the most common di
seases among older men, particularly in Western society. Several years ago,
only age, race, and family history were known risk factors for this diseas
e. However, today, much progress has been made towards discovering nutritio
nal and hormonal risk factors for prostate cancer. Biomarkers, including te
stosterone and insulin-like growth factor, and nutritional factors, especia
lly meat, fat, and daily intake, have been linked to greater risk of diseas
e. Higher consumption of selenium and vitamin E, fructose/fruits, and tomat
oes all have been associated with reduced occurrence of prostate cancer, bu
t as yet their efficacy for prevention remains unproven. The challenge of u
nderstanding the enigmas of this disease will continue into future decades,
as we convert current Knowledge into preventive and therapeutic recommenda
tions.