Use of Cremophor LE as a co-surfactant of lipid emulsions in total parenteral nutrition

Authors
Devillaz, MP Carre-Auger, E Barbieux, A
Citation
Mp. Devillaz et al., Use of Cremophor LE as a co-surfactant of lipid emulsions in total parenteral nutrition, STP PHARM S, 8(5), 1998, pp. 317-321
Citations number
27
Categorie Soggetti
Pharmacology & Toxicology
Journal title
STP PHARMA SCIENCES
ISSN journal
11571489 → ACNP
Volume
8
Issue
5
Year of publication
1998
Pages
317 - 321
Database
ISI
SICI code
1157-1489(199809/10)8:5<317:UOCLAA>2.0.ZU;2-X
Abstract
The aim of this study was to optimize the stability of lipid emulsions in t otal parenteral nutrition. The influence of Cremophor LE, an amphiphilic su rfactant, on the stability of lipid emulsions was assessed using a floccula tion technique. Methods and results are detailed in this paper. Cremophor L E appears to be a useful co-surfactant which increases the resistance of li pid emulsions to destabilizing ion-induced stress.