The symptomatology of neurasthenia, in ICD-10 categorised as neurotic, diso
rder, is very closely related to the somatoform disorders. In recent time,
the diagnostic label neurasthenia was replaced by the research criteria of
chronic fatigue syndrome (CFS). Fatigue and fatigue related symptoms are ve
ry common complaints in the population. We give an overview of the internat
ional empiric literature on neurasthenia and CFS between 1980 and 1997. Whi
le there is a considerable body of literature about diagnostic criteria, ep
idemiology and course of these disorders, empirical literature about the ev
idence of therapeutic intervention, especially of psychodynamic psychothera
py is very rare. Empirically proven management guidelines are reported.