p53 tumor suppressor gene in acoustic neuromas

Alterations of the p53 tumor suppressor gene in 21 cases with acoustic neur oma were investigated by polymerase chain reaction-restriction fragment pol ymorphism (PCR-RFLP) and single strand conformation polymorphism (PCR-SSCP) . Neither mutation nor deletion was found. In 13 informative cases, no loss of heterozygosity (LOH) was confirmed. Thus our results further substantia te the scant contribution of p53 gene tumorigenesis and cell proliferation to acoustic neuromas.