Comparison of relapse and long-term survival between pylorus preserving and whipple pancreaticoduodenectomy in periampullary cancer

BACKGROUND: Whether long-term survival and type of recurrence in periampull ary cancer are influenced by the type of surgical procedure or not is still obscure. The purpose of this review was to analyze the results at a single institution. METHODS: Between 1982 and 1996, 113 consecutive patients with either distal bile duct or ampullary cancers underwent either pylorus-preserving pancrea ticoduodenectomy (PPPD) or the Whipple procedure. The median follow-up was 30 months (range 12 to 150). Patient records were reviewed to determine typ e of recurrence and survival. RESULTS: In distal bile duct or ampullary cancers, comparison of actuarial survival curves between PPPD and the Whipple operation revealed no signific ant differences. Even in node-positive patients, the 5-year survival rates did not differ significantly between those undergoing PPPD or the Whipple o peration. Tumor recurrence was not correlated with the operative method, al though among types of tumor recurrence, the rate of blood-borne metastasis was higher in distal bile duct or ampullary cancers. CONCLUSIONS: PPPD is an acceptable alternative to the Whipple procedure in the treatment of periampullary cancer. Long-term survival and type of recur rence were not influenced by these types of surgical procedures. Am J Surg. 1998; 176:467-470. (C) 1998 by Excerpta Medica, Inc.