Joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli results from overexpression of hipA

Authors
Falla, TJ Chopra, I
Citation
Tj. Falla et I. Chopra, Joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli results from overexpression of hipA, ANTIM AG CH, 42(12), 1998, pp. 3282-3284
Citations number
17
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
42
Issue
12
Year of publication
1998
Pages
3282 - 3284
Database
ISI
SICI code
0066-4804(199812)42:12<3282:JTTBAF>2.0.ZU;2-#
Abstract
The basis of joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli mediated by hipA was examined. An antibiotic tolerance phenotype mas produced by overexpression of hipA under conditions that did not affect the growth rate of the organism. Overexpressing hipA probably d ecreases the period in which bacteria are susceptible to the antibiotics by temporarily affecting some aspect of chromosome replication or cell divisi on.