Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyr4 and parC

Authors
Gibreel, A Sjogren, E Kaijser, B Wretlind, B Skold, O
Citation
A. Gibreel et al., Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyr4 and parC, ANTIM AG CH, 42(12), 1998, pp. 3276-3278
Citations number
24
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
42
Issue
12
Year of publication
1998
Pages
3276 - 3278
Database
ISI
SICI code
0066-4804(199812)42:12<3276:REOHRT>2.0.ZU;2-0
Abstract
Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 1 25 mu g of ciprofloxacin per ml in clinical isolates was associated with ch romosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in th e gyrA product and a Arg-139-Gln substitution in the parC product.