Alteration in the GyrA subunit of DNA gyrase acid the ParC subunit of DNA topoisomerase IV in quinolone-resistant clinical isolates of Staphylococcusepidermidis

Authors
Li, ZY Deguchi, T Yasuda, M Kawamura, T Kanematsu, E Nishino, Y Ishihara, S Kawada, Y
Citation
Zy. Li et al., Alteration in the GyrA subunit of DNA gyrase acid the ParC subunit of DNA topoisomerase IV in quinolone-resistant clinical isolates of Staphylococcusepidermidis, ANTIM AG CH, 42(12), 1998, pp. 3293-3295
Citations number
16
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
42
Issue
12
Year of publication
1998
Pages
3293 - 3295
Database
ISI
SICI code
0066-4804(199812)42:12<3293:AITGSO>2.0.ZU;2-E
Abstract
We examined 22 clinical isolates of Staphylococcus epidermidis to analyze t he association of alterations in GyrA and ParC with fluoroquinolone resista nce. The simultaneous presence of GyrA and ParC alterations was associated with a high level of fluoroquinolone resistance in the clinical isolates of S. epidermidis.