Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus

Authors
Kim, YS Liu, QX Chow, LL Chambers, HF Tauber, MG
Citation
Ys. Kim et al., Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus, ANTIM AG CH, 42(12), 1998, pp. 3325-3327
Citations number
31
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
42
Issue
12
Year of publication
1998
Pages
3325 - 3327
Database
ISI
SICI code
0066-4804(199812)42:12<3325:CEOTIE>2.0.ZU;2-B
Abstract
The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-se nsitive, methicillin-resistant Staphylococcus aureus strain in the rabbit m odel of endocarditis. Trovafloxacin was more effective than van; comycin (C FU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard d eviation]; P < 0.05) or ampicillin-sulbactam plus rifampin (4.9 +/- 1.1 CFU /g). The addition of ampicillin-sulbactam to trovafloxacin tended to reduce titers further.