Me. Abd El-fattah, A novel synthesis of heterocyclic compounds containing coumarin moiety of potential antimicrobial activity, ARCH PH RES, 21(6), 1998, pp. 723-728
The chemical behaviours of 4-methyl-2-oxo-2H-benzopyran-7-yl oxoacetyl hydr
azine (2) towards some different reagents such as anhydride compounds, arom
atic aldehydes, carbon disulphide, and nitrous acid yielded the correspondi
ng pathalazine derivatives (3, 4, 5), hydrazone derivative (6), I,3,4-oxadi
azole derivative (7, 8, 9) and acid azide (10) respectively. Treatment of 1
0 with absolute alcohols, amines and ethyl amino acid ester gave the corres
ponding carbamate derivative (11), substituted urea derivative (12) and eth
yl substituted alkyl acetate (13) respectively. The biological activity of
some synthesized compounds was evaluated.