A novel synthesis of heterocyclic compounds containing coumarin moiety of potential antimicrobial activity

The chemical behaviours of 4-methyl-2-oxo-2H-benzopyran-7-yl oxoacetyl hydr azine (2) towards some different reagents such as anhydride compounds, arom atic aldehydes, carbon disulphide, and nitrous acid yielded the correspondi ng pathalazine derivatives (3, 4, 5), hydrazone derivative (6), I,3,4-oxadi azole derivative (7, 8, 9) and acid azide (10) respectively. Treatment of 1 0 with absolute alcohols, amines and ethyl amino acid ester gave the corres ponding carbamate derivative (11), substituted urea derivative (12) and eth yl substituted alkyl acetate (13) respectively. The biological activity of some synthesized compounds was evaluated.