Screening and isolation of antibiotic resistance inhibitors from herb materials - IV - Resistance inhibitors from Anetheum graveolens and Acorus gramineus

The hexane fractions from methanolic extracts of Anetheum graveolens L. (Um belliferae) and Acorus gramineus Soland. (Araceae) revealed potent inhibito ry activities against the resistance of multi-drug resistant Staphylococcus aureus SA2 when combined with ampicillin (Am) or chloramphenicol (Cm). As active principles, carvone and the liquid mixture containing carvone from A netheum graveolens L. and a liquid mixture mainly consisting of benzoic aci d phenylmethyl ester (benzyl benzoate) from Acorus gramineus Soland. were i dentified. They showed resistance inhibition at the level of 20 similar to 50 mu g/ml when combined with 100 or 50 mu g/ml of Am or Cm, respectively.