Synthesis and biological evaluation of novel 2-[substituted acetly]-amino-5-alkyl]-amino-5-alkyl-1,3,4-thiadiazoles

Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazole were syn thesized and screened for their pharmacological activities. A few of the co mpounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significant non-specific spasmo lytic activity. Diuretic activity of compound 15 at a dose level of 90 mg/k g p.o. was two fold higher compared to 50 mg/kg p.o. of furosemide. Compara ble diuresis was also produced by compounds 9, 10 and 16.