The VLDL receptor: an LDL receptor relative with eight ligand binding repeats, LR8

The discovery in 1992 of a member of the low density lipoprotein receptor ( LDLR) family with eight ligand binding repeats (LR8) has raised more questi ons than have been answered to date. Here, we summarize the current status of knowledge about this intriguing molecule, generally termed VLDL receptor , at the molecular biological, cell biological, and physiological levels. O n one hand, the wealth of reports concerning the role(s) of this receptor i n lipoprotein metabolism in mammalian systems has revealed partially confli cting details, particularly in regards to its natural ligand(s) and site of action. On the other hand, molecular genetic and biochemical studies in th e chicken have clearly demonstrated the multiple roles of LR8 in the physio logy and reproduction of egg-laying species, and have generated insights in to the evolutionary aspects of the LDLR gene family. (C) 1998 Elsevier Scie nce Ireland Ltd. All rights reserved.