A. Gardemann et al., Association of the insertion/deletion gene polymorphism of the apolipoprotein B signal peptide with myocardial infarction, ATHEROSCLER, 141(1), 1998, pp. 167-175
Citations number
42
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
The Del allele of the apolipoprotein B (apoB) signal peptide (SP) insertion
/deletion (Ins/Del) polymorphism has been shown to be associated with eleva
ted plasma levels of apoB, cholesterol and low density lipoprotein. It was
the aim of the present study to analyse the relation of this gene variation
to the risk of coronary artery disease (CAD) and of myocardial infarction
(MI) in a population of 2259 male Caucasians, whose coronary anatomy was de
fined by means of coronary angiography. ApoB SP DelDel genotypes had signif
icantly higher apoB plasma concentrations than InsIns homozygotes (P = 0.00
01) and InsDel heterozygotes (P = 0.002); however, the apoB plasma levels o
f InsIns and InsDel genotypes were essentially the same (P = 0.54). Similar
observations were made with respect to ApoB SP genotype-dependent choleste
rol plasma concentrations. Since the apoB plasma level was not only associa
ted with the apoB SP Ins/Del gene variation but also to the extent of coron
ary artery disease (P < 0.0001), individuals with an InsIns genotype and wi
thout CAD had the lowest and subjects with a DelDel genotype and triple ves
sel disease the highest apoB plasma levels (P < 0.0001). An association of
the apoB SP Ins/Del gene variation with CAD was not detected, neither in th
e total population nor in low risk groups. In contrast, the gene variation
was associated with MI (P < 0.05). An Odds ratio of 1.18 (95% CI, 1.01-1.39
) associated with the Del allele was detected in the total sample (P < 0.02
). In a subpopulation of individuals with low plasma triglyceride levels (<
154 mg/dl; mean value) and an DD genotype of the angiotensin I-converting e
nzyme insertion/deletion gene polymorphism an Odds ratio of 2.01 (1.42-3.05
) was calculated (P < 0.001). The present study presents evidence for a sta
tistically significant difference in the development of MI between genotype
classes of the apoB SP Ins/Del gene polymorphism. (C) 1998 Elsevier Scienc
e Ireland Ltd. All rights reserved.