THE ROLE OF IMMUNOPROTEINS IN THE SURVIVAL OF LIPOSOMES IN THE CIRCULATION

Authors
DEVINE DV MARJAN JMJ
Citation
Dv. Devine et Jmj. Marjan, THE ROLE OF IMMUNOPROTEINS IN THE SURVIVAL OF LIPOSOMES IN THE CIRCULATION, CR R THER, 14(2), 1997, pp. 105-131
Citations number
145
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Critical reviews in therapeutic drug carrier systems
ISSN journal
07434863 → ACNP
Volume
14
Issue
2
Year of publication
1997
Pages
105 - 131
Database
ISI
SICI code
0743-4863(1997)14:2<105:TROIIT>2.0.ZU;2-V
Abstract
The clearance of liposomes from the circulation is mediated largely by the cells of the reticuloendothelial system. These cells recognize li posome-bound immunoproteins, particularly immunoglobulins and compleme nt. This review addresses the state of knowledge of the plasma protein s that can initiate complement activation and antibody binding and the known interactions among these proteins and liposomes, Evidence for t he involvement of immunoproteins and other molecules in the in vivo su rvival of liposomes is also reviewed.