Citation
B. Lal et al., Hydroxyacyl derivatives of forskolin - their positive inotropic activity, BIO MED CH, 6(11), 1998, pp. 2061-2073
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896
→ ACNP
Volume
6
Issue
11
Year of publication
1998
Pages
2061 - 2073
Database
ISI
SICI code
0968-0896(199811)6:11<2061:HDOF-T>2.0.ZU;2-F
Abstract
Using appropriate protection and deprotection sequence novel hydroxyacyl ch
ains of the type CO(CH2)(n)OH are synthesized and are utilized to develop n
ew analogues of forskolin. Several compounds showed good positive inotropic
activity. Compound 12 is almost 10 times more active than forskolin (EC50
= 0.002 mu g/ml).]. (C) 1998 Elsevier Science Ltd. All rights reserved.