In search of novel water soluble forskolin analogues for positive inotropic activity

Authors
Lal, B Gangopadhyay, AK Gidwani, RM Fernandes, M Rajagopalan, R Ghate, AV
Citation
B. Lal et al., In search of novel water soluble forskolin analogues for positive inotropic activity, BIO MED CH, 6(11), 1998, pp. 2075-2083
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
6
Issue
11
Year of publication
1998
Pages
2075 - 2083
Database
ISI
SICI code
0968-0896(199811)6:11<2075:ISONWS>2.0.ZU;2-J
Abstract
Using the novel lead from hydroxy acetyl substituted forskolin analogues, s uch as 7 beta-hydroxyacetyl-7 beta-deacetyl forskolin or 6 beta-hydroxyacet yl forskolin, a number of water soluble omega-amino acyl derivatives were s ynthesized. Two such compounds 6 and 18 showed better in vitro activity but failed to show in vivo activity. (C) 1998 Elsevier Science Ltd. All rights reserved.