Potent, non-thiol inhibitors of farnesyltransferase

Authors
Breslin, MJ deSolms, SJ Giuliani, EA Stokker, GE Graham, SL Pompliano, DL Mosser, SD Hamilton, KA Hutchinson, JH
Citation
Mj. Breslin et al., Potent, non-thiol inhibitors of farnesyltransferase, BIOORG MED, 8(23), 1998, pp. 3311-3316
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
23
Year of publication
1998
Pages
3311 - 3316
Database
ISI
SICI code
0960-894X(199812)8:23<3311:PNIOF>2.0.ZU;2-J
Abstract
The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain a substituted phenyl group at the N terminus, which may occupy a n ovel binding domain on the Ras protein. (C) 1998 Elsevier Science Ltd. All rights reserved.