Synthesis and morphological reversion activity on src(ts)NRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A(1), A(2), and their analogues

Authors
Nakajima, N Enomoto, T Matsuura, N Ubukata, M
Citation
N. Nakajima et al., Synthesis and morphological reversion activity on src(ts)NRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A(1), A(2), and their analogues, BIOORG MED, 8(23), 1998, pp. 3331-3334
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
23
Year of publication
1998
Pages
3331 - 3334
Database
ISI
SICI code
0960-894X(199812)8:23<3331:SAMRAO>2.0.ZU;2-8
Abstract
Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4-9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5-7) showed higher morphological reversion activities on src(ts)NRK cells than 2 and 3. (C) 1998 Elsevier Science Ltd. All right s reserved.