Inhibition of topoisomerase I by naphthoquinone derivatives

Authors
Plyta, ZF Li, TH Papageorgiou, VP Mellidis, AS Assimopoulou, AN Pitsinos, EN Couladouros, EA
Citation
Zf. Plyta et al., Inhibition of topoisomerase I by naphthoquinone derivatives, BIOORG MED, 8(23), 1998, pp. 3385-3390
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
23
Year of publication
1998
Pages
3385 - 3390
Database
ISI
SICI code
0960-894X(199812)8:23<3385:IOTIBN>2.0.ZU;2-G
Abstract
Alkannin and shikonin are naturally occurring naphthoquinones. We have test ed several derivatives of the title compounds and we have found that naphth oquinones bearing at least one phenolic hydroxyl group are potent inhibitor s of topoisomerase I. The ability of the tested compounds to complex Zn++ p arallels with a few exceptions their topoisomerase I inhibition properties while their intercalation and redox properties do not. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.