Synthesis of 2-hydroxy acid from 2-amino acid by Clostridium butyricum

Authors
Khelifa, N Butel, MJ Rimbault, A
Citation
N. Khelifa et al., Synthesis of 2-hydroxy acid from 2-amino acid by Clostridium butyricum, BIOORG MED, 8(23), 1998, pp. 3429-3434
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
23
Year of publication
1998
Pages
3429 - 3434
Database
ISI
SICI code
0960-894X(199812)8:23<3429:SO2AF2>2.0.ZU;2-I
Abstract
Cultures of Clostridium butyricum type strain in synthetic medium supplemen ted with various L-2-amino acids revealed the presence of the corresponding 2-hydroxy acid. This metabolite is able to produce the polyester poly(2-hy droxyalkanoic acid). The bioconversion is not stereoselective since D-2-ami no acids were also converted. Chiral GC analysis demonstrated that only D-e nantiomer is formed from L-leucine. (C) 1998 Elsevier Science Ltd. All righ ts reserved.