M. Fussenegger et Je. Bailey, Molecular regulation of cell-cycle progression and apoptosis in mammalian cells: Implications for biotechnology, BIOTECH PR, 14(6), 1998, pp. 807-833
Regulation of the cell cycle and of programmed cell death (apoptosis) is es
sential for mammalian development and homeostasis, Furthermore, this regula
tion is fundamental to successful cell culture technology acid tissue engin
eering. Therefore the molecular networks which regulate these processes are
critical targets for drug development, gene therapy, and metabolic enginee
ring. This review summarizes the genes, proteins, and interactions presentl
y known to control apoptosis and cell-cycle progression. Knowledge of the n
etworks summarized here and access to the component genes and proteins have
already been applied successfully to guide research and development in bio
process technology and medical treatment.