Jyy. Wang et al., Comparison of the effects of sevoflurane and isoflurane on arterial oxygenation during one lung ventilation, BR J ANAEST, 81(6), 1998, pp. 850-853
Citations number
23
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
We have compared the effects of sevoflurane and isoflurane on arterial oxyg
enation, heart rate and mean arterial pressure during one lung anaesthesia
in a prospective, crossover study. We studied 28 patients undergoing oesoph
agogastrectomy, allocated alternately to one of two groups. Patients in gro
up I/S (n=14) received 1 MAC (1.1%) of isoflurane in oxygen from induction
until the end of 30 min of open chest one lung ventilation (OLV) in the lat
eral position. This was followed by 1 MAC (2.1%) of sevoflurane in oxygen f
or the next 30 min of OLV. Patients in group S/I (n=14) received the two an
aesthetic agents in the reverse order. We found no significant difference i
n arterial oxygenation, heart rate or mean arterial pressure between the tw
o potent inhalation agents. In the subgroup of patients with pulmonary arte
ry catheters (n=12), we found a significant increase (P<0.05) in derived sh
unt during sevoflurane anaesthesia. There was no significant difference in
mixed venous saturation and cardiac output. We conclude that during one lun
g ventilation, the choice between sevoflurane and isoflurane did not signif
icantly influence arterial oxygenation.