Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA

In this randomized, double-blind study, we have compared the ability of 5% liposome-encapsulated tetracaine (amethocaine) (LET) vs 5% eutectic mixture of local anaesthetics (EMLA) to produce local anaesthesia of intact skin i n 40 healthy volunteers. Volunteers had both preparations applied to their forearms under an occlusive dressing for 1 h. Superficial anaesthesia was m easured by a total of nine l-mm pinpricks on each arm. Deeper anaesthesia w as assessed by single insertion of a sterile 22-gauge needle to a depth of 3 mm and pain was reported on a visual analogue scale (VAS). If the volunte er perceived greater than four of the l-mm pinpricks, the 3-mm insertion wa s not performed. Results showed that the number of pinpricks perceived was significantly less (P<0.01) for LET (median 1.0; range 0-9) vs EMLA (1.5; 0 -9). In volunteers who had deeper anaesthesia assessed, there was no signif icant difference (P=0.065) in VAS scores for LET (mean 1.5 (SD 1.4); n=34) vs EMLA (2.4 (2.1); n=28). Overall anaesthetic effect, as ranked by all of the subjects, was significantly better for LET compared with EMLA (P=0.024) . We have demonstrated that when applied in equal volumes, 5% LET produced better superficial local anaesthesia than EMLA.