Acute liver failure induced by alcohol and paracetamol in an HCV-infected haemophiliac

Paracetamol (acetaminophen) is frequently used by haemophiliacs in the mana gement of acute or chronic pain, primarily due to its lack of adverse effec ts when taken at therapeutic doses, We describe acute hepatic and renal tox icity of paracetamol in a 36-year-old patient with haemophilia B, chronic h epatitis C and chronic alcohol abuse. Moderate doses of paracetamol (6 g/d for 4 d), taken with therapeutic intent, resulted in life-threatening organ dysfunction which gradually recovered with full supportive care.