Squamous cell carcinoma of the tongue in a patient with Rothmund-Thomson syndrome

Rothmund-Thomson syndrome is a rare autosomal recessive genodermatosis char acterised by poikilodermatous skin changes that appear in childhood. Patien ts exhibit variable additional features including juvenile cataracts, skele tal abnormalities and a higher than expected incidence of malignancies. We report a case of squamous cell carcinoma of the tongue in a 37-year-old Rot hmund-Thomson syndrome patient and review the natural history of this rare disease, given that the patient was diagnosed with Rothmund-Thomson syndrom e at the age of 8 years and was first reported in 1975.