CD100 is a leukocyte semaphorin

Citation
S. Delaire et al., CD100 is a leukocyte semaphorin, CELL MOL L, 54(11), 1998, pp. 1265-1276
Citations number
69
Categorie Soggetti
Experimental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420682X → ACNP
Volume
54
Issue
11
Year of publication
1998
Pages
1265 - 1276
Database
ISI
SICI code
1420-682X(199811)54:11<1265:CIALS>2.0.ZU;2-0
Abstract
CD100 was originally described as an activation molecule on the surface of human T lymphocytes. Its triggering through distinct epitopes leads to diff erent signals of costimulation with phorbol myristate acetate (PMA) or with CD3 and CD2. Interestingly, CD100 was shown to associate with different pa rtner molecules in T cells. First, CD100 can associate with CD45, a key mol ecule with protein tyrosine phosphatase activity involved in T-cell transdu ction: this association is physical and has functional consequences for bot h partners. Second, CD100 interacts in its cytoplasmic domain with a Ser/Th r kinase for which it represents a preferential substrate. Recently, CD100 was identified as a member of the semaphorin gene family. This family compr ises approximately 20 structurally related proteins. The first semaphorins were identified in the developing nervous system. Function has been shown f or only some of them and involves repulsion during growth cone guidance. Si nce CD100 was the first semaphorin identified in the immune system, this ra ises the possibility of the involvement of members of the semaphorin family in other physiological phenomena outside the nervous system.