Cl. Decunto et al., INFANTILE-ONSET MULTISYSTEM INFLAMMATORY DISEASE - A DIFFERENTIAL-DIAGNOSIS OF SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS, The Journal of pediatrics, 130(4), 1997, pp. 551-556
We describe four unrelated children with neonatal maculopapular rash,
fever, arthritis, hepatosplenomegaly, lymphadenopathy, eye involvement
, and neurologic symptoms. Radiographs of the joints were surprisingly
similar, showing an abnormal epiphyseal and metaphyseal appearance. T
hese clinical and radiologic findings allowed us to include these chil
dren in a very peculiar syndrome described as infantile-onset multisys
temic inflammatory disease. A chondrosarcoma developed in one of our p
atients.