The biosynthesis of pramanicin: intact incorporation of serine and absolute configuration of the antibiotic

Authors
Duspara, P Jenkins, SI Hughes, DW Harrison, PHM
Citation
P. Duspara et al., The biosynthesis of pramanicin: intact incorporation of serine and absolute configuration of the antibiotic, CHEM COMMUN, (23), 1998, pp. 2643-2644
Citations number
15
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
23
Year of publication
1998
Pages
2643 - 2644
Database
ISI
SICI code
1359-7345(199812):23<2643:TBOPII>2.0.ZU;2-B
Abstract
Biosynthetic incorporation of isotopically labelled serines into pramanicin 1 in Stagonospora sp. ATCC 74235 shows that L-serine is incorporated as an intact entity with all four bonds to the alpha-carbon retained; thus 1 is assigned the 5S absolute configuration.