Time-dependent changes of serum carboxy-terminal peptide of type I procollagen and carboxy-terminal telopeptide of type I collagen concentrations in patients with acute myocardial infarction after successful reperfusion: correlation with left ventricular volume indices
T. Murakami et al., Time-dependent changes of serum carboxy-terminal peptide of type I procollagen and carboxy-terminal telopeptide of type I collagen concentrations in patients with acute myocardial infarction after successful reperfusion: correlation with left ventricular volume indices, CLIN CHEM, 44(12), 1998, pp. 2453-2461
To test the hypothesis that in patients with acute myocardial infarction (A
MI), changes in the concentrations of the serum carboxy-terminal peptide of
type I procollagen (PICP) and the carboxy-terminal telopeptide of type I c
ollagen (ICTP) reflect extracellular matrix reformation and degradation, re
spectively, in the infarct healing processes, we measured these serum conce
ntrations by RIA and compared their values with left ventricular (LV) indic
es obtained by left ventriculography. We studied 13 consecutive patients wi
th their first AMI who underwent successful reperfusion. Blood samples were
taken the day of admission and on days 2, 3, 4, 5, 7, and 14. LV volume in
dices were determined at 1 month after AMI, when LV remodeling was almost c
ompleted. The serum concentrations of both PICP and ICTP changed in a time-
dependent manner. The average serum PICP concentration was lower than 1 SD
below the mean control values on days 2 and 3 and increased thereafter, ret
urning to the lower end of the control range at day 14. The area under the
curve (AUC) for PICP was significantly correlated with the LV end systolic
(ES) and end diastolic (ED) volume indices and LV ejection fraction for the
first 14 days after AMI. The serum PICP on days 5-14 was inversely correla
ted or tended to be correlated with the LVES and LVED volume indices. The a
verage serum ICTP concentrations on admission were within the control range
, began to increase on day 2, and reached maximal concentrations on day 5,
remaining at a plateau concentration until day 14. Although the AUC of ICTP
for 14 days, the ICTP concentrations on days 1 and 14, and the minimal and
maximal concentrations were significantly correlated with creatine kinase
(CK) release and the period from AMI onset to the peak CK time, the concent
rations were not significantly correlated with any LV indices except for th
e concentration on day 4, which was weakly correlated with the LVES volume
index. The serum concentrations of PICP showed a significant time-dependent
change that correlated with LV indices, indicating that PICP may provide a
dditional information for evaluating the healing process because it affects
LV remodeling after AMI. Although the serum concentration of ICTP changed
in association with CK release, the ICTP concentration was found to be a po
or indicator for LV indices.