C. Cajochen et al., MELATONIN AND S-20098 INCREASE REM-SLEEP AND WAKE-UP PROPENSITY WITHOUT MODIFYING NREM SLEEP HOMEOSTASIS, American journal of physiology. Regulatory, integrative and comparative physiology, 41(4), 1997, pp. 1189-1196
The pineal hormone melatonin has been implicated in the circadian regu
lation of sleep. In a crossover design, we investigated the effect of
acute administration of 5 mg melatonin and a melatonin agonist (S-2009
8, 5 and 100 mg) in healthy young men when given 5 h before bedtime on
sleep structure and electroencephalogram (EEG) power density. Each tr
ial comprised a baseline, a treatment, and a posttreatment sleep episo
de. Relative to the placebo condition, all treatments phase advanced t
he core body temperature rhythm [Krauchi, K., C. Cajochen, D. Mori, C.
Hetsch, and A. Wirz-Justice. Sleep Res. 24: 526, 1995; and Krauchi, K
., C. Cajochen, D. Mori, and A. Wirz-Justice. Am. J. Physiol. 272 (Reg
ulatory Integrative Comp. Physiol. 41): R1178-1188, 1997]. Rapid eye m
ovement (REM) sleep was increased after both melatonin and S-20098. Th
is increase in REM sleep was most pronounced in the first REM sleep ep
isode. On the posttreatment night after melatonin and S-20098 administ
ration, more wakefulness was present in the latter one-half of the sle
ep episode. EEG power density between 0.25 and 20 Hz during either non
-REM (NREM) or REM sleep did not differ from placebo. Thus a single ea
rly evening dose of melatonin or the agonist S-20098 increases REM sle
ep propensity and advances sleep termination while, at the same time,
the EEG in NREM sleep remains unaffected.