This article discusses the application of GC/MS instrument techniques to ur
ine drug testing. Remember that GC/MS is a technique combining gas liquid c
hromatography (GLC) separation with mass spectrometric detection. This mean
s that good GC/MS results are highly dependent on good chromatographic para
meters. Although it may seem self-evident, many users encounter GC.MS probl
ems that could be readily avoided by optimizing chromatographic parameters.
In fact, most GC/MS problems in the clinical or forensic toxicology labora
tory are probably chromatographic in nature.