Citation
Ma. Elsohly et al., GC/MS analysis of m-hydroxybenzoylecgonine in urine - Forensic implicationin cocaine use, CLIN LAB M, 18(4), 1998, pp. 699
Citations number
11
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
CLINICS IN LABORATORY MEDICINE
ISSN journal
02722712
→ ACNP
Volume
18
Issue
4
Year of publication
1998
Database
ISI
SICI code
0272-2712(199812)18:4<699:GAOMIU>2.0.ZU;2-T
Abstract
m-Hydroxybenzoylecgonine (m-OH-BE) and d3-m- hydroxybenzoylecgonine (d3-m-O
H-BE) have been synthesized, and a GC/MS procedure with d3-m-OH-BE as inter
nal standard has been developed. Among 24 human urine specimens that were p
ositive for BE, all of them have shown detectable levels of m-OH-BE with 75
% of the specimens exceeding the LoQ (5 ng/mL), compared with only 50% of t
he specimens containing detectable levels of EME. The presence of m-OH-BE i
n urine suggested that this metabolite may serve as a valuable marker of co
caine use in addition to BE and EME.