Twenty-four month comparison of apolipoproteins A-1, A-II, and B in contraceptive implant users (Norplant (R) and Implanon (R)) in Birmingham, UnitedKingdom

A e-year prospective, randomized study of 60 implant users was performed to evaluate fasting serial serum apolipoprotein A-I, A-II, and B levels befor e insertion and every 3 months in users of two contraceptive implants relea sing levonorgestrel (Norplant(R)), and 3-ketodesogestrel/etonogestrel (Impl anon(R)) in Birmingham, United Kingdom. All changes in serum apolipoprotein concentrations, irrespective of an increase or decrease, were smaller than one standard deviation of the mean concentration at baseline and did not e xceed the normal range for the laboratory, thus implying no evidence of an increased risk of coronary heart disease. (C) 1998 Elsevier Science Inc. Al l rights reserved.