Mutators and long-term molecular evolution of pathogenic Escherichia coli O157 : H7

Authors
Whittam, TS Reid, SD Selander, RK
Citation
Ts. Whittam et al., Mutators and long-term molecular evolution of pathogenic Escherichia coli O157 : H7, EM INFECT D, 4(4), 1998, pp. 615-617
Citations number
27
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
EMERGING INFECTIOUS DISEASES
ISSN journal
10806040 → ACNP
Volume
4
Issue
4
Year of publication
1998
Pages
615 - 617
Database
ISI
SICI code
1080-6040(199810/12)4:4<615:MALMEO>2.0.ZU;2-B
Abstract
It has been proposed that an increased mutation rate (indicated by the freq uency of hypermutable isolates) has facilitated the emergence of Escherichi a coli O157:H7. Analysis of the divergence of 12 genes shows no evidence th at the pathogen has undergone an unusually high rate of mutation and molecu lar evolution.