Diseases in nontesticular organs can have adverse effects on the male repro
ductive system. The association of hypogonadism and feminization with cirrh
osis of the liver is a classic example but these features may occur with ot
her chronic illnesses;Elevated gonadotropin levels indicate a primary testi
cular disorder. In contrast, acute critical conditions including severe tra
uma or illness and starvation produce hypogonadism by gonadotropin suppress
ion. Many drugs have side effects on the reproductive system.