SYSTEMIC LUPUS-ERYTHEMATOSUS WITH ACANTHOSIS NIGRICANS, HYPERPIGMENTATION, AND INSULIN-RECEPTOR ANTIBODY

Acanthosis nigricans, insulin receptor antibody, and systemic lupus er ythematosus are associated in the potentially lethal syndrome of type B insulin resistance. Hyperpigmentation has been reported rarely, whil e glucose intolerance is common in these patients. We report an adoles cent girl with acanthosis nigricans, hyperpigmentation, insulin recept or antibody, and systemic lupus erythematosus without glucose intolera nce. Insulin resistance may be mild or transient in some patients with type B insulin resistance. Resolution of skin lesions was noted durin g therapy of SLE, and was associated with disappearance of insulin rec eptor antibody.