Lr. Duska et al., Masculinizing sclerosing stromal cell tumor in pregnancy: report of a caseand review of the literature, EUR J GYN O, 19(5), 1998, pp. 441-443
Purpose: To report a case of sclerosing stromal cell tumor of the ovary in
pregnancy and to review the literature of this rare ovarian tumor.
Methods: The patient's office record and hospital record were reviewed. Gro
ss and microscopic pathology were reviewed by one gynecologic pathologist.
A Medline literature search and literature review were performed.
Results: Over eighty cases of sclerosing stromal cell tumor of the ovary ha
ve been reported in the literature since the definition of this pathologic
condition in 1973. Only five cases have been reported during pregnancy and
only two of these resulted in maternal virilization. This report describes
severe maternal virilization with birth of a non-virilized female infant.
Conclusion. Sclerosing stromal cell tumor of the ovary can result in severe
virilization via androgen production. Surgery with removal of the involved
ovary is required for diagnosis and cure. Prognosis is excellent.