Significance of tissue polypeptide specific antigen (TPS) in diagnosis andmonitoring of treatment in ovarian cancer

Tissue polypeptide specific antigen (TPS) finds increasingly broad applicat ion in diagnosis and monitoring of treatment in ovarian cancer. Its sensiti vity increases in parallel to clinical advancement of the tumor and to the grade of cellular differentiation. TPS may represent valuable supplementati on of conventional markers in diagnosis of mucous carcinoma. Improved sensi tivity and specificity of the technique for detection of ovarian cancer occ ur when two or more additional tumour markers are used in parallel. TPS has been found to represent a dependable index of surgical completeness . Determination of TPS in the sera of patients with ovarian cancer in the c ourse of chemical treatment provides important information on the course of the neoplastic process and defines the response of the host to the applied treatment.