Gamma probe-guided sentinel mode biopsy - optimal timing for injection

Citation
S. Schneebaum et al., Gamma probe-guided sentinel mode biopsy - optimal timing for injection, EUR J SUR O, 24(6), 1998, pp. 515-519
Citations number
21
Categorie Soggetti
Oncology
Journal title
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
ISSN journal
07487983 → ACNP
Volume
24
Issue
6
Year of publication
1998
Pages
515 - 519
Database
ISI
SICI code
0748-7983(199812)24:6<515:GPSMB->2.0.ZU;2-2
Abstract
Aims. We initiated a Phase I feasibility study using a gamma-detecting prob e (GDP) and radiolabelled colloid to localize the sentinel lymph node (SLN) in breast cancer. The aim of the study was to establish the ideal timing f or injection and examine any possible exclusion criteria for this method. Methods. Thirty breast cancer patients diagnosed by fine needle aspiration (FNA) were included in this study. All were injected with 60 MBq rhenium co lloid labelled with Tc-99m (Tck-17). Scintigraphy was done 20 min, 2, 6 and 25 hours post-injection. Patients were then taken to surgery where they we re injected with patent blue dye. During surgery, the SLN was located with a CDP (Neoprobe(R) Model 1000). In 28 patients, the SLN was identified by s cintigraphy 2 hours after injection, identical to the images seen after 24 hours. Results. In all 28 patients, the SLN was found by the GDP during surgery. I n 26 patients the SLN was dyed blue. The two patients with no SLN localizat ion had received prior radiation. Pathology disclosed SLNs with metastases in seven patients. Two patients had a negative SLN but had an axillary lymp h node replaced by tumour. Conclusions. Two to 24 hours prior to surgery is suitable timing for inject ion. Previous radiotherapy predicts failure for this procedure. Further stu dies are needed to find the exact false-negative rate of this method for br east cancer.