Effects of some sulfur-containing antioxidants on lead-exposed lenses

Lead (Pb) is known to negatively affect glutathione (GSH) metabolism in the lens. The present study examined the effects of Captopril, Taurine, and al pha-Lipoic acid on the Pb-induced GSH depletion and lipid peroxide increase in the lenticular system. Captopril administration returned the GSH, cyste ine (CYS), and malondialdehyde (MDA) levels to near normal. Following Tauri ne administration the GSH, CYS and MDA levels were intermediate between the control group and the Pb group levels, alpha-Lipoic acid administration, h owever, only increased the CYS levels. No significant changes in oxidized g lutathione (GSSG) levels were observed in any treatment group. (C) 1998 Els evier Science Inc.