INHIBITION BY L-NA, A NITRIC-OXIDE SYNTHASE INHIBITOR, OF NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN A MOUSE MODEL OF CHOLESTASIS

Following the naloxone administration in bile duct resected animals, s triking opioid withdrawal signs are observed due to increased opioider gic tone. Pretreatment of animals with L-nitro arginine, a nitric oxid e synthase inhibitor, reduces the naloxone-precipitated withdrawal sig ns as well as increase the antinociception. The results of this study support evidence for the involvement of the L-arg-nitric oxide pathway in opioidergic-dependent manifestation of cholestasis in an animal mo del.