Purpose: The purpose of the study is to report the outcome and postope
rative topographic analysis of seven patients who underwent small-diam
eter, round, eccentric penetrating keratoplasty. Methods: Seven patien
ts underwent small-diameter, round, eccentric penetrating keratoplasty
for a variety of corneal disorders (cataract wound necrosis and dehis
cence or fistula, three patients; penetrating keratoplasty wound infec
tion, two patients; corneal rheumatoid melt and perforation, one patie
nt; localized fungal keratitis, one patient). Full-thickness corneal t
ransplants ranged in size from 3.0 to 5.5 mm. The graft wound and sutu
res spared the visual axis in all cases. Patients were observed for 7
to 42 months (mean, 21 months). All patients had postoperative topogra
phic analysis. One of these also had preoperative analysis. Results: A
ll grafts tectonically were effective in treating the intended conditi
on. Best-corrected visual acuity was 20/30 or better in the four patie
nts without pre-existing corneal transplants or dry eyes; 20/60 and 5/
200 in the patients with previous central penetrating keratoplasties;
and 20/40 in the patient with rheumatoid melt, There was no clinically
significant regular or irregular astigmatism induced centrally by the
eccentric graft in the four patients where visual acuity was 20/30 or
better. Irregular astigmatism was noted in the other three patients.
Conclusion: Small-diameter, eccentric penetrating keratoplasties may b
e used successfully to treat various peripheral corneal disorders. In
some cases, this can be performed without inducing high or irregular a
stigmatism or both centrally.