The current approach to hand infections is a culmination of information gai
ned from centuries of medical teaching by the ancient Creeks, nineteenth-ce
ntury anatomists, and twentieth-century microbiologists and surgeons. Altho
ugh many individuals have contributed to our knowledge through their teachi
ngs and writings, the contemporary treatment of hand infections has evolved
quite rapidly. Several landmark scientific discoveries have drastically ch
anged not only the manner in which hand infections are treated, but the ult
imate clinical results obtained. This brief review of the history of hand i
nfections highlights the major contributions that have influenced the conte
mporary medical and surgical approach to infections of the hand.