Acute pyogenic flexor tenosynovitis usually occurs following a penetrating
injury of the digital flexor tendon sheath. The most common pathogenic orga
nisms are gram positive, although gram-negative and mixed-organism infectio
ns are being encountered with increasing frequency in the immunocompromised
patient. The clinical findings originally described by Kanavel include ten
derness along the sheath, a flexed posture of the involved digit, pain on p
assive extension, and fusiform symmetrical digital swelling. Treatment is d
ependent on several factors, but typically involves surgical drainage, appr
opriate antibiotics, and early rehabilitation. This review article addresse
s the pathophysiology, bacteriology, differential diagnosis, contemporary t
reatment approaches, and complications of acute pyogenic flexor tendon shea
th infections.