Restless legs syndrome is a common condition characterized by unpleasa
nt limb sensations that are precipitated by rest and relieved by activ
ity. Symptoms are worse during the evening and may result in insomnia,
Most cases are idiopathic, although the condition is sometimes famili
al and may be associated with a range of medical illnesses, including
chronic renal failure and iron deficiency anemia. Restless legs syndro
me is responsive to several medications, including levodopa, dopamine
agonists, benzodiazepines, opioids, and some anticonvulsants. A practi
cal approach to management involves a stepwise plan, commencing with i
ntermittent therapy with less potent agents for mild cases and progres
sing to medications with greater potency but a higher potential for si
de effects.