A NEW PHARMACOPHORE OF POTENTIAL ANTIMYCOBACTERIAL ACTIVITY - THE DISULFIDE GROUP IN THE RING OF ALICYCLIC COMPOUNDS

Authors
STACHEL HD ODLEROVA Z WAISSER K
Citation
Hd. Stachel et al., A NEW PHARMACOPHORE OF POTENTIAL ANTIMYCOBACTERIAL ACTIVITY - THE DISULFIDE GROUP IN THE RING OF ALICYCLIC COMPOUNDS, Collection of Czechoslovak Chemical Communications, 62(3), 1997, pp. 510-515
Citations number
8
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
62
Issue
3
Year of publication
1997
Pages
510 - 515
Database
ISI
SICI code
0010-0765(1997)62:3<510:ANPOPA>2.0.ZU;2-A
Abstract
A series of thirty 2,3-dithiabicyclo[3.3.0]octa-4,8-diene derivatives was examined for antimycobacterial activity against Mycobacterium tube rculosis, M. kansasii, M. avium, and M. fortuitum. The structure-activ ity relationships were analysed by Free-Wilson method. The authors con sider the disulfide moiety to be the pharmacophore of antimycobacteria l activity. To verify the idea, several other monocyclic sulfides, 3,4 -dihydro-1,2-dithiolane derivatives, were also evaluated.