Development of a vaccine against Helicobacter pylori infection

In animals, oral immunization can prevent or cure Helicobacter pylori infec tion, and prevent reinfection. Several antigens of the pathogen have been i dentified as protective antigens, and some appear to be well suited for use in an human vaccine. Initial clinical studies have shown that urease is sa fe in humans, and immunogenic in Helicobacter pylori-infected volunteers. T he design of a protective vaccine in humans will probably depend upon the c ombination of two or more antigens, the identification of the optimal route of immunization, and the use of appropriate vaccine delivery systems. Beca use a vaccine against Helicobacter pylori is likely to be effective regardl ess of the mode of transmission of the infection, it represents a potential alternative to current therapies, with the added advantage of having a dir ect impact on the reservoir of the infection.