Light chain deposition disease neuropathy resembling amyloid neuropathy ina multiple myeloma patient

A 65-year-old man with IgG lambda multiple myeloma developed severe polyneu ropathy with prominent thermal-pain sensory impairment and autonomic failur e. Although the clinical presentation suggested amyloid neuropathy, nerve b iopsy showed the immunohistochemical and ultrastructural features typical o f light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.