Prechallenge high neutralizing antibodies and long-lasting immune reactivity to gp41 correlate with protection of rhesus monkeys against productive simian immunodeficiency virus infection or disease development
H. Petry et al., Prechallenge high neutralizing antibodies and long-lasting immune reactivity to gp41 correlate with protection of rhesus monkeys against productive simian immunodeficiency virus infection or disease development, J ACQ IMM D, 19(5), 1998, pp. 441-450
To investigate the protective efficacy of various gp130 vaccine preparation
s, rhesus monkeys were immunized with gp130 oligomers (O-gp130) or two diff
erent gp130-monomer preparations (M1-gp130; M2-gp130) and challenged with 5
0 MID,, of simian immunodeficiency virus (SIV)mac32H. Following challenge t
he control animals and all animals of the M1- and M2-gp130 group and I anim
al of the O-gp130 group were productively infected, whereas 3 animals of th
e O-gp130 group resisted the productive virus replication. The protection w
as correlated with high neutralizing antibodies and a long-lasting immune r
esponse to the transmembrane protein gp41. Whereas none of the O-gp130 anim
als had developed disease symptoms, 3 M1-gp130 animals, I M2-gp130 animal,
and 2 control animals died as a result of AIDS within 18 months after chall
enge. Therefore, immunization with virion-derived gp130 oligomers of SIVmac
32H can confer protection against the productive infection with SIVmac32H a
nd suppress the development of the AIDS-like disease.